Think NR + Resveratrol Is Enough? Read This and Think Again

If you have looked at popular anti-aging products, you have probably seen NR (nicotinamide riboside) + resveratrol. The idea sounds amazing. NR raises your NAD+ level to support energy in every cell. Resveratrol, the red-wine antioxidant, protects your body from stress and may turn on “longevity enzymes” called sirtuins. On paper, this sounds like a perfect combination. But in real life, things are not that simple.

The problems with NR and resveratrol

Resveratrol sounds powerful, but it has one big issue. Your body does not absorb it well. When you swallow it, most of it is broken down in the stomach, gut, and liver before it can reach your cells. Studies show that less than one percent usually makes it into your bloodstream. Even if a supplement label says 500 milligrams, your body may only use a very small amount.

To make up for this, many brands use very high doses. Large doses often bring side effects such as nausea, stomach pain, diarrhea, or headaches. Some research also shows that too much resveratrol can disturb your body’s redox balance, which is the natural system that controls oxidation and antioxidants. When this balance is upset, your cells can actually become more stressed instead of protected.

There is another hidden issue inside your cells. When NAD+ is used, it produces a byproduct called nicotinamide, also known as NAM. If too much NAM builds up, it can block sirtuins, the same enzymes that resveratrol is supposed to activate. That means large amounts of NR and resveratrol together can sometimes cancel out part of their benefits.

Scientists also do not yet know what happens when people take this combination for many years. Most studies last only a few months, and the long-term safety, especially for older adults, is still unclear.

A smarter and safer upgrade

That is why OptiNourish NAD+ Optimal takes a better approach. It keeps what truly works.

Instead of resveratrol, it uses pterostilbene, a natural compound found in blueberries. Pterostilbene is very similar to resveratrol but has small chemical differences that help your body absorb it more easily. It also stays in your blood longer, so you receive more benefits from smaller amounts.

OptiNourish also includes herbal antioxidants that work in different ways throughout your body. They help balance oxidation, support circulation, and protect your cells without overwhelming them. By combining several gentle antioxidants instead of one heavy dose, your body maintains its own natural rhythm of repair and protection.

Support your cells in a smarter way. Choose OptiNourish NAD+ Optimal!

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References

Smoliga JM et al. Enhancing the Delivery of Resveratrol in Humans: If Low Bioavailability is the Problem, What is the Solution? https://pmc.ncbi.nlm.nih.gov/articles/PMC6270951/

Kapetanovic IM et al. Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and pterostilbene. https://pmc.ncbi.nlm.nih.gov/articles/PMC3090701/

Briskey D et al. Trans-Resveratrol Oral Bioavailability in Humans Using LipiSperse Delivery. https://pmc.ncbi.nlm.nih.gov/articles/PMC7763804/

Brown K et al. Resveratrol for the Management of Human Health: Clinical Evidence and Side Effects. https://www.mdpi.com/1422-0067/25/2/747

Shaito A et al. Potential Adverse Effects of Resveratrol: A Literature Review. https://pmc.ncbi.nlm.nih.gov/articles/PMC7139620/

Bitterman KJ et al. Inhibition of Silencing and Accelerated Aging by Nicotinamide. https://www.jbc.org/article/S0021-9258%2819%2971610-X/fulltext

Imai S-i, Guarente L. It takes two to tango: NAD+ and sirtuins in aging/longevity control. https://www.nature.com/articles/npjamd201617

Orr ME et al. A randomized placebo-controlled trial of nicotinamide riboside in older adults with MCI. https://pmc.ncbi.nlm.nih.gov/articles/PMC10828186/

Liu Y et al. Recent Advances in Synthesis, Bioactivity, and Pharmacokinetics of Pterostilbene. https://pmc.ncbi.nlm.nih.gov/articles/PMC7664215/